a global observation study of type 2 diabetes - Considerations when planning and conducting large global observational

a global observation study of type 2 diabetes - Diabetes remains a substantial public health biobet for diabetes issue Type 2 diabetes which makes up the bulk of diabetes cases is largely preventable and in some cases potentially reversible if identified and managed early in the disease course However all evidence indicates that diabetes prevalence is increasing worldwide primarily due to a rise in obesity caused by multiple factors Preventing and Type 2 diabetes mellitus T2DM has reached pandemic levels posing significant challenges to global public health systems The World Health Organization WHO projects that over 9 of the global adult population will be affected by 2030 1 The latest Global Burden of Disease GBD data indicate that in 2021 529 million individuals worldwide were living with diabetes with 960 of these DISCOVER is a global programme of observational research that includes patients with type 2 diabetes initiating secondline glucoselowering therapy from 38 countries worldwide including many with little or no previous epidemiological data available More than 15000 patients were followedup for 3 years and comprehensive data were collected using a standardized electronic case report form Age distribution of diabetes mellitus type 2 worldwide A Incidence vs prevalence both 2017 B Incidence in 1990 vs 2017 p 00001 chisquare test Even though it afflicts individuals later in life type 2 diabetes ranks seventh among the leading causes of disability and years of life lost DALYs Global regional and national burden of diabetes from 1990 to 2021 Global regional and national burden of diabetes from 1990 to 2021 Background The United Nations acknowledged diabetes as an epidemic of the 21st century Global trends demonstrate a continuing growth in its prevalence at approximately 25 per year The aim of the study was to analyse selected epidemiological factors for type 2 diabetes mellitus in Poland Central Europe and the World Methods This study presents Global Burden of Disease GBD data Study Diabetes is a worldwide epidemic with an estimated 463 million patients currently having either type 1 or type 2 diabetes ayo kita kenali diabetes melitus tipe 2 5 This number is predicted to rise to 700 million by 2045 with type 2 diabetes accounting for over 90 of all cases Global burden of type 2 diabetes in adolescents and young The BMJ Global regional and national burden of type 2 diabetes mellitus Epidemiology of Type 2 Diabetes Global Burden of Disease and Epidemiological factors for type 2 diabetes mellitus evidence from the Considerations when planning and conducting large global observational Objective To estimate the global burden of type 2 diabetes in adolescents and young adults aged 1539 years from 1990 to 2019 Design Systematic analysis Data source Global Burden of Disease Study 2019 Participants aged 1539 years from 204 countries and territories 19902019 Main outcomes measures Age standardised incidence rate age standardised disability adjusted life years DALY Using the most recent evidentiary and analytical framework from the Global Burden of Diseases Injuries and Risk Factors Study GBD we produced locationspecific agespecific and sexspecific estimates of diabetes prevalence and burden from 1990 to 2021 the proportion of type 1 and type 2 diabetes in 2021 the proportion of the type 2 Global regional and national burden of diabetes from 1990 to 2021 Estimates trends and drivers of the global burden of type 2 diabetes Type 2 diabetes is a major global health concern contributing to approximately 15 million deaths 31 million years of life lost and 35 million years lived with disability in 2019 GBD is the most comprehensive global epidemiological study It estimates the burden of disease from 286 causes of death 369 diseases and injuries and 87 Research in context Evidence before this study The Global Burden of Diseases Injuries and Risk Factors Study GBD generates publicly available estimates of total inclusive of type 1 and type 2 diabetes deaths prevalence years of life lost YLLs years lived with disability YLDs and disabilityadjusted lifeyears DALYs at the global superregion region and country and Considerations when planning and arti dm adalah conducting large global observational

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