advance diabetes study pdf - Study rationale and design of ADVANCE beer lower risk of diabetes action in diabetes and vascular disease preterax and diamicron MR controlled evaluation Diabetologia 20014411181120 Crossref The ADVANCE study randomized 11140 participants at sites in Europe AustraliaNew Zealand Canada and Asia to a strategy of intensive glycemic control with primary therapy being the sulfonylurea gliclizide and additional medications as needed to achieve a target A1C of 65 or to standard therapy in which any medication but gliclizide PDF A summary of the ADVANCE trial ResearchGate A Summary of the ADVANCE Trial Diabetes Care diabetes1214 The Action in Diabetes and Vascular Disease Preterax and Diamicron Modified Release Controlled Evaluation ADVANCE trial was designed to assess the effects on major vascular outcomes The ADVANCE trial The Lancet Effects of Intensive Glucose Lowering in Type 2 Diabetes The ADVANCE Trial is the largestever study aimed at investigating the effects of a treatment based on the fixed combination of an ACEinhibitor perindopril 2mg and a diuretic agent indapamide 0625mg on macrovascular and microvascular complications and deaths The main features of ADVANCE can be summarised as follows Simon R Heller on behalf of the ADVANCE Collaborative Group A Summary of the ADVANCE Trial 1 November 2009 32 suppl2 S357S361 The publication of the UK Prospective Diabetes Study UKPDS in 1998 helped to shape the management of type 2 diabetes in recent years 1 The study demonstrated several points PDF The ADVANCE trial The Lancet Intensive Blood Glucose Control and Vascular Outcomes in Patients with PDF A Summary of the ADVANCE Trial Semantic Scholar The ADVANCE study1 claims that a regimen bkerangka terjadinya peristiwa diabetes of perindopril and indapa mide reduces vascular morbidity and mortal ity in patients with type 2 diabetes and one other vascular risk factor Since more than half of the patients in the control group were taking perindopril by the end of the study the major diff erence in treatment was in diuretic use The aim of the BP arm of the ADVANCE trial was to establish whether routine provision of BPlowering therapy produced additional benefits in terms of macro and microvascular disease irrespective of baseline BP and added to the benefits produced by other cardiovascular preventive therapies including ACE inhibitors The publication of the UK Prospective Diabetes Study UKPDS in 1998 What did the ACCORD ADVANCE and VA Diabetes trials show The ADVANCE Trial results clinical implications and perspectives Intensive Blood Glucose Control and Vascular Outcomes in Patients with Supplementary Appendix nejmadvance2560sa1pdf Download 24053 KB Appendix UK Prospective Diabetes Study UKPDS Group Intensive bloodglucose control with sulphonylureas or insulin The ADVANCE study1 claims that a regimen of perindopril and indapamide reduces vascular morbidity and mortality in patients with type 2 diabetes and one other vascular risk factor Since more than half of the patients in the control group were taking perindopril by the end of the study the major difference in treatment was in diuretic use This suggests that the benefit came from the effect By the end of the trial over 90 of patients were still taking a sulfonylurea gliclazide MR in the intensive group compared with 69 in those allocated to standard bekam penderita diabetes therapy total of 74
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