alloxan induced diabetes mechanism and effects - PDF Alloxaninduced diabetes a common model arti gds dalam kesehatan for evaluating the Pdf Alloxan Monohydrate Induced Diabetes a Comprehensive Review The mechanism of action of alloxan in order to induce diabetes mellitus in experimental animals is highlighted and it is found to be selectively toxic to pancreatic beta cells Diabetes mellitus is a metabolic disorder constituting a major health concern today whose prevalence has continuously increased worldwide over the past few decades Moreover it has been considered as an incurable Diabetes trials of alloxan monohydrate have been one of the most used diabetes chemicals The action mechanism in β cells has been thoroughly studied and understood quite well PDF The mechanisms of alloxan and streptozotocininduced diabetes Springer AlloxanInduced Diabetes Mellitus an overview ScienceDirect Alloxaninduced diabetes a common model for evaluating the glycemic This study evaluated the longterm effects of alloxaninduced diabetes in rat liver Methods Thirty nondiabetic control rats NC and 30 untreated diabetic UD rats were divided into three subgroups sacrificed after 6 14 or 26 weeks Clinical and laboratory parameters were assessed Alloxan and streptozotocin are toxic glucose analogues that preferentially accumulate in pancreatic beta cells via the GLUT2 glucose transporter In the presence of intracellular thiols especially glutathione alloxan generates reactive oxygen species ROS in a cyclic redox reaction with its reduction product dialuric acid Autoxidation of dialuric acid generates superoxide radicals Alloxan Induced Diabetes Mechanisms and Effects ResearchGate Alloxaninduced diabetes is a form of insulindependent diabetes mellitus that occurs as a result of alloxan administration or injection to animals 78 79It has been harga diabmine obat diabetes successfully induced in a variety of animal species rabbits mice rats monkeys cats and dogs 80 81Alloxan has been administered in single or multiple doses through different routes intraperitoneal intravenous and Alloxan and streptozotocin are the most popular diabetogenic agents used for assessing the antidiabetic or hypoglycemic capacity of test compounds Notably alloxan is far less expensive and more Alloxan is a cyclicurea derivative which is a highly effective diabetogenic agent used widely as a tool to induce experimental diabetes Diabetes follows the alloxaninduced destruction of the pancreatic islet beta cell and in the appropriate dose it is selective to islet beta cell producing minimal effects on other structures Cooperstein AlloxanInduced Diabetes Causes Morphological and Ultrastructural Download Citation Alloxan Induced Diabetes Mechanisms and Effects Diabetes mellitus is a metabolic disorder constituting a major health concern today whose prevalence has continuously Alloxan Induced Diabetes Mechanisms and Effects Alloxan mechanism of action Alloxan has two distinct pathological effects it selectively inhibits glucoseinduced insulin secretion through specific inhibition of glucokinase the glucose sensor of Fig 1 Phasic blood glucose response to a diabetogenic dose of alloxan tetraphasic IIV or streptozotocin triphasic the first phase The mechanism of alloxaninduced diabetes in laboratory animals has been under investigation since Dunn and McLetchie reported in 1943 that the compound produced permanent hyperglycemia The effects of alloxaninduced diabetes on lipid metabolism has been studied in numerous reports RomanLopez and Allred 1987 Yamada et al 2003 The mechanisms of alloxan and streptozotocininduced diabetes Springer AlloxanInduced Diabetes type 2 diabetes headaches Mellitus an overview ScienceDirect
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