alloxan induced diabetes mechanism and effects rohilla - PDF Alloxan Induced Diabetes Mechanisms and obat diabetes daun seri Effects Alloxan and streptozotocin are the most popular diabetogenic agents used for assessing the antidiabetic or hypoglycemic capacity of test compounds Notably alloxan is far less expensive and more readily available than streptozotocin On this ground one will logically expect a preference for use of alloxan in experimental diabetes studies Experimental diabetic animal models to study diabetes and diabetic Alloxan Induced Diabetes Mechanisms and Effects Alloxan 2456tetraoxypyrimidine2456pyrimidinetetrone is an oxygenated pyrimidine derivative which is present as alloxan hydrate in aqueous solution Brugnatelli originally isolated The type of diabetes that the experimental animal models replicate as well as the mechanism of induction such as spontaneous naturally occurring induced by chemicaldrug physical or by genetic changes transgenic models are used to categorize them 1213 Here are a few frequently utilized models for creating diabeteslike animals Rohilla A and Ali S 20I2 Alloxan induced diabetes mechanisms and Alloxan and streptozotocin are toxic glucose analogues that preferentially accumulate in pancreatic beta cells via the GLUT2 glucose transporter In the presence of intracellular thiols especially glutathione alloxan generates reactive oxygen species ROS in a cyclic redox reaction with its reduction product dialuric acid Autoxidation of dialuric acid generates superoxide radicals Alloxaninduced diabetes a common model for evaluating the glycemic Alloxaninduced diabetes is a form of insulindependent diabetes mellitus that occurs as a result of alloxan administration or injection to animals 78 79It has been successfully induced in a variety of animal species rabbits mice rats monkeys cats and dogs 80 81Alloxan has been administered in single or multiple albumin rendah pada penderita diabetes doses through different routes intraperitoneal intravenous and Notably alloxan is far less expensive and more readily available than streptozotocin On this ground one will logically expect a preference for use of alloxan in experimental diabetes studies Diabetes was induced in mice using alloxan which is a wellestablished method 58 Alloxan induces diabetes by damaging the insulinsecreting pancreatic βcells resulting in a decrease in Alloxaninduced diabetes a common model for evaluating the glycemic The mechanisms of alloxan and streptozotocininduced diabetes Springer PDF Alloxaninduced diabetes a common model for evaluating the The mechanism of action of alloxan in order to induce diabetes mellitus in experimental animals is highlighted and it is found to be selectively toxic to pancreatic beta cells Diabetes mellitus is a metabolic disorder constituting a major health concern today whose prevalence has continuously increased worldwide over the past few decades Moreover it has been considered as an incurable PDF The mechanisms of alloxan and streptozotocininduced diabetes Springer Alloxan mechanism of action Alloxan has two distinct pathological effects it selectively inhibits glucoseinduced insulin secretion through specific inhibition of glucokinase the glucose sensor of Fig 1 Phasic blood glucose response to a diabetogenic dose of alloxan tetraphasic IIV or streptozotocin triphasic the first phase Alloxan Induced Diabetes Mechanisms and Effects ResearchGate Rohilla A and Ali S 20I2 Alloxan induced diabetes mechanisms and effects Int J Res Pharma Biomed Sci 3 819823 has been cited by the following article Article Effect of Curcumin Extracts on the Islets of Langerhans Cells of Diabetic White Rats Induced by apa yang menyebabkan diabetes melitus Alloxan A Histological Study
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