alloxan monohydrate dose to induced diabetes in rats 125 - Analogous to toxic glucose alloxan typically kaki diabetes parah accumulates through the existing glucose conveyor GLUT2 in pancreatic βcells The dose requirement for alloxan differs to cause diabetes varies Alloxan induced diabetes in 3333 of rats receiving either 150 mgkg or 160 mgkg of alloxan and 60 of rats receiving 170 mgkg dose All surviving rabbits given alloxan via rapid iv injection developed diabetes compared to 60 of surviving rabbits given slow iv injection The effects of aqueous extract of alfalfa on blood glucose Antidiabetic effects were assessed by inducing diabetes in Wistar albino rats n 5 six groups included 30 rats by injecting alloxan 025 mgkg body weight bw intraperitoneally and efficacy of methanol extracts of leaf and bark and aqueous extract of leaves were evaluated by oral administration of 300 mgkg bw of extracts for 3 weeks Alloxaninduced diabetes a common model for evaluating the Alloxaninduced diabetes causes morphological and PubMed Rat model of foodinduced nonobesetype 2 diabetes mellitus A triphasic blood glucose response to the diabetogenic dose of alloxan was observed reactive hyperglycemic phase phase 1 hypoglycemic phase phase 2 and hyperglycemic diabetic phase phase 3 The details in terms of BGLs and timeframes are displayed in Figures 1 ab 2 and 3 PDF ALLOXAN MONOHYDRATE INDUCED DIABETES A COMPREHENSIVE Seven days after alloxan monohydrate injection for confirming the diabetic state in rats blood glucose of rats was measured and rats with blood glucose concentration more than 200 mg100 cc that were diabetics have been selected 8 rats of 10 reach to diabetic state The first control group is injected by physiologic serum for equivalency Glycosylated haemoglobin values of alloxaninduced diabetic A New model for Alloxaninduced diabetes mellitus in rats The effects of dosage and the routes of administrations of Diabetes was induced using intravenous alloxan Sigma Co USA at a dose of 42 mgkg of body weight into tail veins Only animals with clinical signs of severe diabetes and fasting glucose 250 mgdL in two successive determinations 1 and 2 weeks after diabetes induction were used Diabetes was induced in rats using the method described by Venugopal et al Citation 1998 The rats were injected with alloxan monohydrate Sigma Aldrich UK dissolved in distilled water at a dose of 160 mgkg body weight intraperitoneally after overnight fasting 18 h Rutin ameliorates metabolic acidosis and fibrosis in alloxan Alloxaninduced diabetes is a form of insulindependent diabetes mellitus that occurs as a result of alloxan administration or injection to animals 78 79 It has been successfully induced in a variety of animal species rabbits mice rats monkeys cats and dogs 80 81 Abstract Uncertainties have existed regarding the systematic induction and management of druginduced diabetes mellitus DM Issues have included the optimal route of administration of the drug methods of reducing drug toxicosis and mortality how to induce type1 versus type2 DM and how to manage labile DM in rats Practical considerations for reducing mortality rates in Streblus asper attenuates alloxaninduced diabetes in accu diabetes rats Diabetes was induced using intravenous alloxan Sigma Co USA at a dose of 42 mgkg of body weight into tail veins Only animals with clinical signs of severe diabetes and fasting glucose 250 mgdL in two successive determinations 1 and 2 weeks after diabetes induction were used The present study aimed to clarify the effects of Arabic gumGum Acacia GA on the biochemical histopathological and immunohistochemical changes observed in diabetic rats Further the Group II rats were induced diabetes with a single dose of alloxan monohydrate 150 mgkg body weight in 09 saline intraperitoneally Group III rats received 028 M of NH 4 Cl in drinking water for 3 days for the experimental induction of metabolic acidosis Hypoglycemic Effects in AlloxanInduced Diabetic Rats of the DM was induced in the first group by single intraperitoneal injection of 150mgkg alloxan monohydrate and in the second group by feeding the rats with diet of high glycemic indexlow fat for 8 weeks The pathophysiology and histopathology of DM were studied Hyperglycemia was recorded in the alloxan and foodinduced groups respectively Alloxan An unpredictable drug for diabetes induction PMC The rats were injected with alloxan monohydrate in saline 09 NaCl at a dose of 120 mgkg bw intraperitoneally to induce diabetes in 8 h fasted male Sprague Dawley rats weighing 180200 g After one hour of alloxan administration the animals were given feed ad libitum Induction of type1 diabetes mellitus in laboratory rats by Levels of fasting blood glucose of diabetic rats which were injected with alloxan at a dose of 150 mgkg one week before the zero day ie 0 day were all higher than 20 mmolL as indicated by the dashed line Figure 1b DC PMID 25789328 PMCID PMC4350960 DOI 1011552015494578 Abstract Purpose This study evaluated the longterm effects of alloxaninduced diabetes in rat liver Methods Thirty nondiabetic control rats NC and 30 untreated diabetic UD rats were divided into three subgroups sacrificed after 6 14 or 26 weeks Arabic gum ameliorates systemic modulation in Alloxan In our study we found that Alloxan at dose of 140 mgkg ip and 120 mgkg sc is optimal dose in inducing high rate of diabetes As well as Chougale et al tried to investigate on the optimization of Alloxan dose to induce stable diabetes for prolonged period AlloxanInduced Diabetes Causes Morphological and Optimization of Alloxan Dose is Essential to Induce Stable Antidiabetic Effect of Sida cordata in Alloxan Induced AlloxanInduced Diabetes Causes Morphological and Alloxan dose for experimental induction of diabetes in rats has to be optimized Lower doses can result in autoreversion to normal state without medical help while higher doses cause toxicity and loss of experimental animals Induction of stable diabetes for prolonged period is needed for studies on various parameters in diabetes A single intraperitoneal injection of freshly prepared alloxan monohydrate 150mgkg bw and at a concentration of 20mgml was used to induced diabetes in overnight fasted american diabetes association guidelines perioperative rats 12 After 3
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