antidepresan untuk penderita diabetes - Objective Depression may be difficult to obat herbal cina diabetes treat and with comorbid diabetes mellitus DM it is an even bigger challenge This article aims to evaluate antidepressants most suitable for patients with depression and comorbid DM Design and methods Initially we searched for randomised controlled doubleblind trials of treatment with antidepressants in depressed with DM but there were only a few Antidepressants and type 2 diabetes highways to knowns and unknowns Type 2 diabetes T2D is a metabolic disease caused by the development of insulin resistance IR relative insulin deficiency and hyperglycemia Hyperglycemiainduced neurochemical dysregulation activates the progression of depression in T2D patients Therefore management of depression by antidepressant agents improves glucose homeostasis and insulin sensitivity However prolong use of Antidepressants for depressed patients with type 2 diabetes PubMed This network metaanalysis compared the shortterm treatment effects of different antidepressants on depression severity and HbA1c in depressed patients with type 2 diabetes mellitus T2DM We searched 8 to 24week randomizedcontrolled trials RCTs in PubMed Scopus Web of Science Cochrane Central Register of Controlled Trials and Depression is common in patients with type 2 diabetes mellitus T2DM and can cause serious consequences It affects approximately 23 of men with T2DM and 37 of women with T2DM Khaledi et al 2019Patients with diabetes have an odds of depression development 133 times higher than those with no diabetes Chireh et al 2019T2DM comorbid with depression usually results in poor glycemic Antidepressant Pharmacotherapy in Adults With Type 2 Diabetes Antidepressant Medication as a Risk Factor for Type 2 Diabetes and Antidepressant use and diabetes mellitus risk a metaanalysis Associations Between Antidepressant Use and Advanced Diabetes Outcomes Use of antidepressants in patients with depression and PubMed Incident patients with diabetes with depressive disorders were included if they had at least 2 ambulatory or 1 inpatient diagnosis of depressive disorder ICD9CM code 2962 2963 3004 or 311 within 1 year before gejala penyakit gula the cohort entry date n 38 537 In order to have at least a 6month observation period to quantify the association between Association Between the Use of Antidepressants and the Risk of Type 2 The results of followup after type 2 diabetes onset are shown in Tables 3 and 4 and in Supplementary Fig 2 Among 1950 patients with newonset type 2 diabetes in the exposure group 1651 had a prescription for antidiabetes drugs or insulin injections and 1 among the remaining 299 switched medications The other 298 were followed up Antidepressant Medication as a Risk Factor for Type 2 Diabetes and Antidepressants for depressed patients with type 2 diabetes mellitus A Diabetes was diagnosed by an annual oral glucose tolerance test or fasting plasma glucose every 6 months using the 1997 American Diabetes Association criteria At baseline 57 of participants were taking antidepressants Intermittent antidepressant use was reported for 72 of total personyears and continuous antidepressant use for 32 of Diabetes Care 20103326112616 PMC free article Google Scholar 19 Kivimäki M Tabák AG Lawlor DA et al Antidepressant use before and after the diagnosis of type 2 diabetes a longitudinal modeling study Diabetes Care 20103314711476 PMC free article Google Scholar 20 Brown LC Majumdar SR Johnson JA Background Epidemiologic studies have reported inconsistent findings regarding the association between the use of antidepressants and type 2 diabetes mellitus DM risk We performed a metaanalysis to systematically assess the association between antidepressants and type 2 DM risk Methods We searched MEDLINE PubMed EMBASE and the Cochrane Library through Dec 31 2011 including Clinically significant depression often occurs in the context of medical illness It is present in one of every four patients with diabetes is highly recurrent and imposes additional risks of poor diabetes selfcare hyperglycemia diabetes complications and death Randomized controlled trials demonstrate the efficacy of pharmacotherapy 6 apa perbedaan diabetes melitus dengan diabetes insipidus 8 cognitive behavior therapy
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