antioxidant enzyme alterations in experimental and clinical diabetes - Antioxidant Enzymes and Lipid Peroxidation in apa yang dimaksud dengan diabetes inpidus Type 2 Diabetes Mellitus Previous studies from our laboratory have demonstrated the presence of complex alterations in the activities of antioxidant enzymes in various tissues of rats with streptozotocin STZinduced diabetes In the present investigation it is shown that rats made diabetic with alloxan ALX an agent differing from STZ both chemically and in its mechanism of diabetogenesis show virtually D iabetes is widely recognised as one of the leading causes of death and disability worldwide1 The prevalence of diabetes will rise from 6 to over 10 in the next decade2 In 2000 the World Health Organization WHO recorded a total of 171 million people for all age groups worldwide 28 of the global population who have diabetes and the numbers are expected to rise to 366 million 44 Antioxidant enzyme alterations in experimental and clinical diabetes Antioxidant enzyme alterations in experimental and clinical diabetes Antioxidant enzyme alterations in experimental and clinical diabetes Oxidative stress and the use of antioxidants in diabetes Linking basic Summary Defence against the reactive oxidants produced during aerobic metabolism is a complex process and is provided by a system of enzymes and antioxida It is shown that rats made diabetic with alloxan ALX an agent differing from STZ both chemically and in its mechanism of diabetogenesis show virtually identical tissue antioxidant enzyme changes which as is the case with STZ are preventable by insulin treatment Previous studies from our laboratory have demonstrated the presence of complex alterations in the activities of antioxidant The finding that the patterns of antioxidant enzyme alterations in chemicallyinduced diabetes are independent of the diabetogenic agent used and the presence of similar abnormalities in tissues of spontaneously diabetic BB Wistar rats particularly when diabetic control is less than optimal suggest that the changes observed are terapi non farmakologi diabetes melitus tipe 2 a Results The malondialdehyde MDA levels and catalase CAT activity were significantly increased and reduced glutathione GSH levels and activities of glutathione peroxidase GPx and glutathione reductase GR were significantly decreased in Type2 DM with and without nephropathy as compared to controls and also in Type2 DM with nephropathy as compared to Type2 DM without nephropathy The authors summarise experimental and clinical investigations in this field and analyse the possible importance of the changes in the antioxidant system in the development of diabetic vascular complications Antioxidant enzyme alterations in experimental and clinical diabetes Mol Cell Biochem 1988 Dec 84 2223231 PDF Antioxidant enzyme alterations in experimental and clinical diabetes It should be emphasized that clinical trials with antioxidants in diabetes are limited and majority of these trials focused on the use of vitamin E and C and lately αlipoic acid Thus we will attempt to group the clinical trials by the antioxidants used Small trials with vitamin E demonstrated beneficial cardiovascular effects Alterations in enzymatic antioxidant defence in diabetes mellitus a The Role of Oxidative Stress and Antioxidants in Diabetic Complications Alterations in enzymatic antioxidant defence in diabetes mellitus a hibit alterations in antioxidant enzyme activities in rats with various forms of experimental diabetes and in human diabetics The results in Table 2 show that in ALXinduced diabetes activities of GSHPX and GSSGRD in red cells are significantly increased The fact that these enzyme alterations are preventa Europe PMC is an archive of life sciences journal literature Do data resources managed by EMBLEBI and our collaborators make a difference to your work If so please take 10 minutes to fill in our survey and help us make the case for why sustaining open data resources is critical for life sciences research Antioxidant enzyme alterations in apa penyebab diabetes kering experimental and clinical diabetes
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