aterosklerosis pada diabetes - Diabetes mellitus DM and its complications asociaciÓn americana de diabetes ada pose a serious threat to human health and have become a global public health issue 12 Over 90 of patients with diabetes have type 2 DM T2DM 34 Diabetes and Atherosclerosis an Overview Atherosclerosis is the most common complication of diabetes Epidemiologic and pathophysiologic evidence suggest a number of possible reasons for this They include alterations in lipoproteins platelets soluble clotting factors the balance of prostacyclinthromboxane blood pressure regulation and Diabetes and Atherosclerosis an Overview A simplified scheme of the pathophysiological connection of diabetes mellitus and atherosclerosis Dyslipidemia hyperglycemia and insulin resistance result in a spectrum of physiological changes including the formation of atherogenic lowdensity lipoprotein LDL advanced glycation end products AGE and activation of proinflammatory signaling that impact different cell types of the Clinical relationships between diabetes and atherosclerosis are well established The majority of the clinical and experimental data regarding the onset of diabetes complications are associated with atherosclerosis suggesting that the impact of chronic hyperglycaemia might induce damage on vascular homeostasis mainly attributable to the endothelium function The Diabetes MellitusAtherosclerosis Connection The Role of Lipid and Atherosclerosis StatPearls NCBI Bookshelf The link between diabetes and atherosclerosis Lucia La Sala Diabetes and Atherosclerosis Mechanisms and Management Smooth muscle cell proliferation is an important pathologic finding in atherosclerosis This process is stimulated by a platelet mitogen which has been partially characterized The mitogen has not been studied in diabetes Lipid accumulation in the area of the atherosclerotic lesion is primarily in the form of intracellular and extracellular Diabetes mellitus comprises a group of carbohydrate metabolism disorders that share asupan pemberian gizi untuk diabetes a common main feature of chronic hyperglycemia that results from defects of insulin secretion insulin action or both Insulin is an important anabolic hormone and its deficiency leads to various metabolic abnormalities in proteins lipids and carbohydrates Context Complications of atherosclerosis cause most morbidity and mortality in patients with diabetes mellitus Despite the frequency and severity of disease proven medical therapy remains incompletely understood and underused Objective To review the epidemiology pathophysiology and medical and invasive treatment of atherosclerosis in patients with diabetes mellitus Pathogenesis of Atherosclerosis in Diabetes Mellitus Diabetes and atherosclerosis epidemiology pathophysiology and Diabetes profoundly affects the pathogenesis of atherosclerosis through various mechanisms Established cardiovascular risk factors are more prevalent in diabetic than in nondiabetic patients Although trials of intensive glycemic control have been somewhat disappointing for decreasing atherogenesis the results of trials with lipidregulating Atherosclerosis is one of the main complications of diabetes involving multiple causative factors Dysfunction of the vascular endothelium is a hallmark of most conditions that are associated with both diabetes and atherosclerosis Although the pathological link between diabetes and atherosclerosis is wellestablished better comprehension of Diabetic vascular diseases molecular mechanisms and therapeutic The link between diabetes and atherosclerosis PubMed The Diabetes MellitusAtherosclerosis Connection The Role of Lipid and Atherosclerosis is a chronic inflammatory disease of the arteries and is the underlying cause of about 50 of all deaths in westernized society It is principally a lipiddriven process initiated by the accumulation of lowdensity lipoprotein and remnant lipoprotein particles and an active inflammatory process in focal areas of arteries particularly at regions of analisis kadar glukosa dan kadar ldl terhadap tikus wistar diabetes disturbed nonlaminar flow at
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