atherosclerosis in diabetes mellitus - Keywords atherosclerosis diabetes mellitus NLRP3 endothelial akibat diabetes tipe 2 dysfunction hyperglycemia dyslipidemia NLRP3 inhibitor Introduction Diabetes mellitus is a major and growing problem worldwide not only in the socalled developed countries 1 2 According to a recent report from the International Diabetes Federation about 537 million The link between diabetes and atherosclerosis Lucia La Sala AbstractPreviously diagnosed diabetes mellitus newly diagnosed diabetes mellitus and impaired glucose tolerance are important determinants of the risk of clinical cardiovascular disease CVD Eckfeldt JH A prospective study of coronary heart disease in relation to fasting insulin glucose and diabetes the Atherosclerosis Risk in Diabetes and Atherosclerosis Mechanisms and Management The Diabetes MellitusAtherosclerosis Connection The Role of Lipid and The Diabetes MellitusAtherosclerosis Connection The Role of Lipid and Diabetes as a noncommunicable chronic disease NCD represents the major cause of loss of productive life in the European Union EU and premature mortality due to a high incidence of cardiovascular complications cardiovascular diseases CVDs 1 Among the diabetes population 90 are affected by type 2 diabetes mellitus T2DM and 10 by type 1 diabetes mellitus T1DM Keywords atherosclerosis diabetes mellitus cardiovascular disease chronic inflammation lipid metabolism hyperglycemia 1 Introduction Atherosclerosis is a widespread chronic inflammatory disorder of the arterial wall that often leads to disability and even death At its final stages atherosclerosis manifests itself as a lesion of the Diabetes Mellitus and Cardiovascular Disease Arteriosclerosis Atherosclerosis accounts for virtually 80 of all diabetesrelated mortality It is also a principal reason for hospitalization of patients with diabetes Diabetes profoundly affects the pathogenesis of atherosclerosis through various mechanisms Established cardiovascular risk factors are more prevalent in diabetic than in nondiabetic patients manfaat tape singkong untuk diabetes It was shown that both types of diabetes mellitus can actually induce atherosclerosis development or further accelerate its progression Elevated glucose level dyslipidemia and other metabolic alterations that accompany the disease development are tightly involved in the pathogenesis of atherosclerosis at almost every step of the atherogenic Cardiovascular disease remains the principal cause of death and disability among patients with diabetes mellitus Diabetes mellitus exacerbates mechanisms underlying atherosclerosis and heart failure Unfortunately these mechanisms are not adequately modulated by therapeutic strategies focusing solely on optimal glycemic control with currently available drugs or approaches In the setting of Atherosclerosis is the most common complication of diabetes Epidemiologic and pathophysiologic evidence suggest a number of possible reasons for this They include alterations in lipoproteins platelets soluble clotting factors the balance of prostacyclinthromboxane blood pressure regulation and arterial smooth muscle cell metabolism and Dyslipidemia Diabetes and Atherosclerosis Role of Inflammation and Clinical Update Cardiovascular Disease in Diabetes Mellitus Diabetes and Atherosclerosis an Overview Diabetes Mellitus Arteriosclerosis Thrombosis and Vascular Biology Cardiovascular disease remains a leading cause of morbidity and mortality in people with types 1 or 2 diabetes mellitus Although beneficial roles for strict control of hyperglycemia have been suggested such a strategy is not without liabilities Specifically the risk of hypoglycemia and its consequences remain an omnipresent threat with such approaches The advent of the CVOT Diabetes Mellitus Promotes the Development of Atherosclerosis The Role Diabetes is associated with accelerated atherosclerosis leading to widely distributed vascular lesions including cardiovascular disease CVD coronary artery disease cerebrovascular disease and peripheral arterial disease 123 with CVD being the major cause of akibat terkena diabetes premature death in diabetes
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