biological age in diabetes mellitus - Biological age in diabetes and precision apakah akurat mengukur diabetes dibawah 2 jam setelah makan medicine Aging Chronological age CA is determined by time of birth whereas biological age BA is based on changes on a cellular level and strongly correlates with morbidity mortality and longevity Type 2 diabetes T2D associates with increased morbidity and mortality thus we hypothesized that BA would be 969P Diabetes Mellitus Is Associated with Increased Biological Age Biological age BA closely depicts agerelated changes at a cellular level Type 2 diabetes mellitus T2D accelerates BA when calculated using clinical biomarkers but there is a large spread in the magnitude of individuals age acceleration in T2D suggesting additional factors contributing to BA Additionally it is unknown whether BA can be changed with treatment We hypothesized that Diabetes mellitus correlates with increased biological age as indicated PDF Diabetes mellitus correlates with increased biological age as Diabetes mellitus correlates with increased biological age as indicated Chronological age CA is determined by time of birth whereas biological age BA is based on changes on a cellular level and strongly correlates with morbidity mortality and longevity Type 2 diabetes T2D associates with increased morbidity and mortality thus we hypothesized that BA would be increased and calculated it from biomarkers collected at routine clinical visits Deidentified For example diabetes mellitus type 2 positively correlates with advancing age and causes glucose intolerance in humans Bahour et al 2022 whereas aged mice become more glucose tolerant Biological age BA closely depicts agerelated changes at a cellular level Type 2 diabetes mellitus T2D accelerates BA when calculated using clinical biomarkers but there is a large spread in the magnitude of individuals age acceleration in T2D suggesting additional factors contributing to BA Additionally it is unknown whether BA can be changed with diabetes melitus adalah pdf treatment Most patients with T2D are above the fifth decade of life suggesting a correlation between cellular age and diabetes This paper identified an increase in biological age a reflection of aging at a cellular level compared to chronological age defined by time since birth in people with diabetes mellitus The significance of these findings is Biological age in diabetes and precision medicine Briana N Cortez 1 2 Nadine Bahour 1 Cristina AguayoMazzucato 1 1 Beta Cell Aging Lab Joslin Diabetes Center Harvard Medical School Boston MA 02215 USA 2 University of Texas Rio Grande Valley School of Medicine Edinburg TX 78539 USA Biological age in diabetes and precision medicine Biological age in diabetes and precision medicine Biological age in diabetes and precision medicine Aging Albany NY 2022 Jun 6141146224623 doi 1018632aging204123 Diabetes Mellitus Epigenesis Genetic Precision Medicine Ages ranged from 2080 years and for analysis persons with diabetes were matched by age and gender to subjects without diabetes Eight clinical biomarkers significantly correlated with CA in people without diabetes pvalues from 11 x1098 to 56 x103 The Klemera and Doubal method KDM was used to calculate BA and results were confirmed Heterogeneity of increased biological age in type 2 diabetes correlates Biological age in diabetes and precision medicine PubMed Heterogeneity of increased biological age in type 2 diabetes correlates Diabetes mellitus correlates with increased biological age as PubMed CA can directly impact biological age BA which specifically measures the rate of cellular decline or physiological breakdown of cells and organs within the body While CA and BA can change at the same rate we found that in Diabetes mellitus BA is accelerated when compared to CA 2 Biological age in diabetes makanan pengganti karbohidrat untuk diabetes and precision medicine PMC
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