biomarker of gestational diabetes - Background Gestational diabetes mellitus GDM one bawang putih utk diabetes of the most common pregnancy complications can lead to morbidity and mortality in both the mother and the infant Metabolomics has provided new insights into the pathology of GDM and systemic analysis of GDM with metabolites is required for The purpose of this review is to provide an overview of the current status of SNPs and the two most commonly investigated epigenetic mechanisms DNA methylation and microRNAs miRNAs as molecular biomarkers for GDM Three major databases PubMed Scopus and Web of Science were searched Prediction of Gestational Diabetes Mellitus in the First Trimester Gestational diabetes mellitus GDM is a type of glucose intolerance disorder that first occurs during womens pregnancy The main diagnostic method for GDM is based on the midpregnancy oral glucose tolerance test The rise of metabolomics has expanded the opportunity to better identify early diagnostic biomarkers Unique Biomarker Characteristics in Gestational Diabetes Mellitus Molecular biomarkers for gestational diabetes mellitus and postpartum In recent years new biochemical and molecular biomarkers such as microRNAs singlenucleotide polymorphisms and DNA methylation have received great interest in the diagnosis of GDM In this review we discuss current and future diagnostic approaches for the detection of GDM and evaluate lifestyle Gestational diabetes mellitus GDM a metabolismrelated pregnancy complication is significantly associated with an increased risk of macrosomia We hypothesized that maternal circulating metabolic biomarkers differed between women with GDM and macrosomia GDMM and women with GDM and normal Gestational diabetes mellitus GDM is one of the most common metabolic complications during pregnancy threatening both maternal and fetal health Prediction and diagnosis of GDM is not unified Finding effective biomarkers for GDM is particularly important for achieving early prediction A FirstTrimester Biomarker Panel for Predicting the Development The studys findings revealed and biomarkers showing the highest potential for early GDM prediction The current research provides a foundation for future studies to refine and expand upon the predictive models aiming for even earlier and more accurate detection methods Keywords gestational diabetes mellitus To develop a first trimester prediction model for gestational diabetes mellitus GDM using obesity placental and inflammatory biomarkersWe used a UCLA researchers focused on extracellular vesicles which deliver microRNA genes within maternal blood Finally urineexcreted metabolites such as those related with serotonin system nonpolar aminoacids and ketone bodies may complete a predictive or earlydiagnostic panel of biomarkers for GDM Keywords Cardiovascular disease Diagnostic biomarkers Gestational diabetes Metabolic disease The diagnostic indicators of gestational diabetes mellitus from Additional file 4 Table of all the biomarkers evaluated divided into category and described with their name abbreviation function The data sets reside with the authors of the original papers evaluated Gestational diabetes mellitus GDM is glucose intolerance first recognised during Genome wide association studies specifically examined GDM instead relying on shared genetic signatures with T2D 113 Common genetic variants CDKAL1 and MTNR1B buah-buahan buat penderita diabetes kolesterol darah tinggi & asam urat found in T2D are significantly associated with GDM 114 Specifically CDKAL1 interacts with signalling molecules Predictive and diagnostic biomarkers for gestational diabetes and The Emerging Role of Biomarkers in the Diagnosis of Gestational Maternal serum biomarkers for risk assessment in gestational diabetes Different biomarkers in the pregnant mother are also used to assess embryonic and fetal normal or abnormal development 2 Among the biomarkers that are used to assess maternal glucose metabolism in pregnancy are glucose tolerance test in the second trimester of pregnancy assessing the presence Triglyceride glycemic TyG index is a novel tool for assessing insulin resistance IR Recently TyG index as a potential biomarker for gestational diabetes mellitus GDM has been studied but its performance is yet inconclusive Thus we Triglyceride glycemic index as a biomarker for gestational diabetes S3 Table Commonly used venous for gestational diabetes using an oral glucose tolerance test PDF S1 Fig Funnel plot of the studies reporting on PAPPA MoM levels among women with and without GDM PDF S2 Fig Forest plot of the studies reporting on PAPPA MoM levels among women with and without GDM stratified by geographic location PDF S3 Fig Forest plot of the studies reporting on PAPPA MoM levels among women with and without GDM stratified by biomarker assay Predictive and diagnostic biomarkers for gestational diabetes and its associated metabolic and cardiovascular diseases A LorenzoAlmorós1 C Peiró2 L SorianoGuillén3 J Egido15 J Tuñón4 Ó Lorenzo ORCID orcidorg000000015515607815 Show authors Cardiovascular Diabetology volume 18 Article number 140 2019 Cite this article Gestational diabetes mellitus GDM is defined as the presence of Gestational diabetes mellitus GDM is associated with adverse maternal and foetal consequences along with the subsequent risk of type 2 diabetes mellitus T2DM and several other diseases Due to early risk stratification in the prevention of progression of GDM improvements in biomarker In this study we describe a novel glycoprotein biomarkers and previously described GDMassociated markers In screening for GDM by multianalyte panel the detection rate was 87 at a falsepositive rate of 1 Keywords Gestational diabetes glycosylated fibronectin These studies clearly demonstrate that various biomarkers reflect pathological changes in GDM The established markers have potential use as screening and diagnostic tools in GDM and in postpartum diabetes research In the present review we summarize recent studies of metabolites singlenucleotide polymorphisms microRNAs and proteins associated with GDM and its transition to postpartum diabetes with a focus on their predictive value in screening and diagnosis Keywords Gestational First trimester prenatal screening biomarkers and gestational Association of body composition in early pregnancy with gestational diabetes mellitus A metaanalysis Rahnemaei FA Abdi F Pakzad R Sharami SH Mokhtari F Kazemian E Rahnemaei FA et al PLoS One 2022 Aug 15178e0271068 doi 101371journalpone0271068 eCollection 2022 PLoS One 2022 PMID 35969611 Free PMC article Diagnostic accuracy of first and early bolehkah penderita diabetes hamil second trimester multiple biomarkers
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