folic acid diabetes - The effects of folate supplementation on 2 etologi diabetes melitus glucose metabolism and risk of The present study aimed to determine the folic acid supplement FAS effects on serum homocysteine and sortilin levels glycemic indices and lipid profile in type II diabetic patients A double Folic acid supplementation significantly revealed a large effect size on homocysteine levels compared to placebo SMD 153 95CI 214093 p 005 Nutrition Diabetes Folic Vitamins and Type 2 Diabetes Mellitus PMC PubMed Central PMC Folic acid effect on homocysteine sortilin levels and Nature Previously several randomized clinical trials reported that folic acid or folate supplementation improved IR 79 and reduced the levels of inflammatory mediators 710 which may beneficially affect T2DM riskHowever prospective cohort studies that directly relate longterm consumptions of folate vitamin B 6 or vitamin B 12 to incident diabetes are limited Folic Acid Supplementation Improves Glycemic Control for Diabetes Folic acid supplementation significantly reduces some markers of glycemic control in adults These reductions were small which may limit clinical applications for adults with type II diabetes Further research is necessary to confirm our findings Associations of folate intake with allcause and causespecific Folic Acid as a Potential Vitamin in Glycemic Control A Systematic Is Folic Acid Beneficial for Diabetes TheDiabetesCouncilcom In an in vivo study conducted by Golbahar et al it was defined that high homocysteine could cause insulin resistance and the researchers underlined that high homocysteine levels should be considered as a risk factor in patients with obesity and type II diabetes Folic acid is essential in determining plasma homocysteine concentrations and is Intakes of Folate Vitamin B penyakit diabetes basah American Diabetes Association Folic acid supplementation on inflammation and homocysteine in type 2 Folic acid is an essential factor in determining plasma Hcy concentrations 11 12 Therefore folic acid supplementation FAS lowers the Hcy level by increasing the 5methyltetrahydrofolate intracellular pool which may improve the overall management of diabetic patients and may decrease cardiovascular events 3 10 The absorption of folic acid and vitamin B 12 is importantly decreased by the prolongued use of metformin which is the first choice drug in uncomplicated diabetes thus these two nutrients have been found deficient in the disease and most probably need to be supplemented regularly On the other hand vitamin D is considered a risk factor for Folic acid effect on homocysteine sortilin levels and glycemic control Folic acid taken along with Vitamin B12 has not been shown to decrease the rates of heart or blood vessel disease in people with diabetes though these supplements DID lower the levels of homocysteine AND did lower the risk of stroke Different types of studies known as observational studies HAVE shown a decrease in heart disease Purpose Observationally homocysteine is associated with higher risk of diabetes Folate which reduces homocysteine is promising for the prevention and treatment of diabetes Previous metaanalysis of three trials suggested folate might lower hemoglobin A 1c HbA 1c Methods An updated systematic review and metaanalysis of placebocontrolled randomized trials was conducted Folic acid supplementation improves glycemic control for diabetes prevention and management a systematic review and doseresponse metaanalysis of randomized controlled trials Nutrients 2021 132355 103390nu13072355 PMC diabetes melitus obat free article Google Scholar
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